The prologue is set in World War II, circa 1945. Nazis break into the laboratory of Dr. Reisendorf and confiscate the heart of the Frankenstein Monster, on which he is busy experimenting. The Nazis travel by submarine to the Pacific. The Allied Forces then bomb their submarine, but not before the Nazis are able to pass the heart (contained in a locked chest) to the Imperial Japanese Navy, who take it back to Hiroshima to be experimented on. But just as they are about to begin, Hiroshima is bombed by the Allied Forces, and the heart is lost.