The Giant Sea Serpent only has a short appearance in the film King Kong Escapes. When the film's central character Susan Watson and her companions are attempting to leave Mondo Island, the Giant Sea Serpent rises out from the water and approaches their craft. On the shore, King Kong, concerned with the safety of Susan then throws a boulder at the serpent to distract it while Susan Watson and her companions escape the serpent and reach their submarine. King Kong goes into the water, and is attacked by the Giant Sea Serpent, who attempts to constrict Kong. After a brief skirmish, Kong frees himself from the Giant Sea Serpent's grasp and tosses him back into the water.
- The Giant Sea Serpent has abilities similar to those of contemporary giant snake Manda.
- The Giant Sea Serpent is a superb swimmer and uses constriction to defeat his enemies.
- The battle with King Kong and the Giant Sea Snake is reminiscent of Kong's bout with the Cave Serpent in the original King Kong film.
- The Giant Sea Serpent is one of the minor Showa era monsters to have received an official toy. The others are the Giant Octopus, the Giant Condor and the Mystery Bones of Infant Island.