The H.E.A.T. Seeker is first seen without any paint as a "state-of-the-art research vessel" offered to Dr. Niko Tatopoulos by Monique Dupre as an incentive to let her stay and make sure that the then-unnamed H.E.A.T. was doing their job. Nick takes the bait and the ship becomes a vital asset to the group, as many of the mutations fought in the series are very far away from New York City. The vessel does not truly become the H.E.A.T. Seeker until Talkin' Trash, where Randy Hernandez coins the H.E.A.T. Acronym and paints the name on the side of the ship, along with its iconic "Shark Face".
- The H.E.A.T. Seeker is outfitted with powerful radar equipment.
- It is equipped with hydrofoils.
- It seems to be inspired by the Calico, the research vessel from Hanna-Barbera's Godzilla.
- The H.E.A.T. Seeker lent its name to a false title called Heat Seekers for the used during production prior to the 1998 movie coming out, where Godzilla was referred to by staff as Gorgon and by the characters Thingy.